Gray DT, Guitierrez A, Jami-Alahmadi Y, Pandey V, Pan L, Zhang Y, Wohlschlegel JA, and De Biase LM. Microglia promote extracellular matrix deposition and restrict excitatory synapse numbers in the mesolimbic dopamine system during healthy aging. (2024) BioRxiv [link]
Godoy MI, Pandey V, Wohlschlegel JA, and Zhang Y. Secretome analysis of oligodendrocytes and precursors reveals their roles as contributors to the extracellular matrix and potential regulators of inflammation. (2024) BioRxiv [link]
Rosenberg MF, Godoy MI, Wade SD, Paredes MF, Zhang Y, and Molofsky AV. b-adrenergic signaling promotes morphologic maturation of astrocytes in mouse. Journal of Neuroscience (2023) [link]
Krawcyzk MC, Godoy MI, Vander P, Zhang AJ, and Zhang Y. Loss of Serpine2 alters antimicrobial gene expression by microglia but not astrocytes. Neurosci Letters (2023) [link]
Li J*, Godoy MI*, Zhang AJ, Diamante G, Ahn IS, Cebrian-Silla A, Alvarez-Buylla A, Yang X, Novitch BG, and Zhang Y. Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis. (2023) BioRxiv [link]
Krawczyk MC, Pan L, Zhang AJ, and Zhang Y. Lymphocyte deficiency alters the transcriptomes of oligodendrocytes, but not astrocytes or microglia. (2023) PLOS One [link]
Pan L, Trimarco A, Zhang AJ, Fujimori K, Urade Y, Sun LO, Taveggia C, and Zhang Y. Oligodendrocyte-lineage cell exocytosis and L-type prostaglandin D synthase promote oligodendrocyte development and myelination. (2023) eLife (This is an accepted paper under eLife’s old publication model. It is NOT a reviewed preprint under eLife’s new publication model) [link]
Leng K, Rose IVL Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, TCW J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann DS, Kampmann M. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. (2022) Nature Neuroscience [link]
Sapkota D, Kater MSJ, Sakers K, Nygaard KR, Liu Y, Lake AM, Khazanchi R, Khankan RR, Smit AB, Maloney SE, Verheijen MHG, Zhang Y, Dougherty JD. Activity dependent translation in astrocytes dynamically alters the proteome of the perisynaptic astrocyte process. (2022) Cell Reports. [link]
Krawczyk MC, Haney JR, Pan L, Caneda C, Khankan RR, Reyes SD, Chang JW, Morselli M, Vinters HV, Wang AC, Cobos I, Gandal MJ, Bergsneider M, Kim W, Liau LM, Yong WH, Jalali A, Deneen B, Grant GA, Mathern GW, Fallah A, and Zhang Y. Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic Signatures. (2022) Journal of Neuroscience. [link]
Li Z, Siddique I, Hadrovic I, Kirupakaran A, Li J, Zhang Y, Klarner F-G, Schrader T, Bitan G. Lysine-selective molecular tweezers are cell-penetrant and concentrate in lysosomes. (2021) Communications Biology [link]
Li J, Pan L, Godoy MI, Pembroke WG, Rexach JE, Condro MC, Alvarado AG, Harteni M, Chen YW, Stiles L, Chen AY, Wanner IB, Yang X, Goldman SA, Geschwind DH, Kornblum HI, and Zhang Y. Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes. (2021) Nature Communications. 12 (1): 3958 [link]
Li J*, Khankan RR*,Caneda C, Godoy MI, Haney MS, Krawczyk MC, Bassik MC, Sloan SA, and Zhang Y. Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation. (2019) Glia 67(8): 1571-1597 [link]
Watanabe M, Buth JE, Vishlaghi N, de la Torre-Ubieta L, Taxidis J, Khakh BS, Coppola G, Pearson CA, Yamauchi K, Gong D, Dai X, Damoiseaux R, Aliyari R, Liebscher S, Schenke-Layland K, Caneda C, Huang EJ, Zhang Y, Cheng G, Geschwind DH, Golshani P, Sun R, and Novitch BG. Self-organized cerebral organoids with human-specific features predict effective drugs to combat Zika virus infection (2017) Cell Reports 21 (2): 517-532 [link]
Darmanis S, Sloan SA, Croote D, Mignardi M, Chernikova S, Samghababi P, Zhang Y, Neff N, Kowarsky M, Caneda C, Li G, Chang SD, Connolly ID, Li Y, Barres BA, Gephart MH, and Quake SR. Single-cell RNA-seq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma (2017) Cell Reports 21 (5): 1399-1410 [link]
Zhang Y*, Sloan SA*, Clark LE, Caneda C, Plaza CA, Blumenthal PD, Vogel H, Steinberg GK, Edwards MSB, Li G, Duncan JA, Cheshier SH, Shuer LM, Chang EF, Grant GA, Hayden Gephart MG, and Barres BA. Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse. (2016) Neuron 89 (1): 1-17 [link]
Larson VA, Zhang Y, and Bergles DE. (2016) Electrophysiological properties of NG2+ cells: Matching physiological studies with gene expression profiles. Brain Res. 1638: 138-160. PMID: 26385417 [link]
Dong X, Chen K, Duran R, You Y, Sloan SA, Zhang Y, Zong S, Cao Q, Barres BA, and Wu JQ. Comprehensive identification of long non-coding RNAs in purified cell types from the brain reveals functional lncRNA in OPC fate determination. (2015) Plos Genetics 11(12): e1005669. [link]
Darmanis S, Sloan SA, Zhang Y, Enge M, Caneda C, Shuer LM, Hayden-Gephart MG, Barres BA, Quake SR. A survey of human brain transcriptome diversity at the single cell level. (2015) Proceedings of the National Academy of Sciences 112 (23): 7285-7290. PMID: 26060301 [link]
Yan Q, Weyn-Vanhentenryck SM, Wu J, Sloan SA, Zhang Y, Chen K, Wu JQ, Barres BA, and Zhang C. (2015) Systematic discovery of regulated and conserved alternative exons in the mammalian brain reveals NMD modulating chromatin regulators. Proceedings of the National Academy of Sciences 112 (11), 3445-3450. PMID: 25737549 [link]
Zhang Y*, Chen K*, Sloan SA*, Bennett ML, Scholze AR, O'Keeffe S, Phatnani HP, Guarnieri P, Caneda C, Ruderisch N, Deng S, Liddelow SA, Zhang C, Daneman R, Maniatis T, Barres BA, and Wu JQ. (2014) An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex. Journal of Neuroscience 34, 11929–11947. PMID: 25186741 [link]
Zhang Y and Barres BA. (2013) A smarter mouse with human astrocytes. Bioessays 35: 876-880. PMID: 23897758 [link]
Zhang Y and Barres BA. (2010) Astrocyte heterogeneity: an underappreciated topic in neurobiology. Curr Opin Neurobiol 20: 588–594. PMID: 20655735 [link]
Zheng Y*, Wildonger J*, Ye B, Zhang Y, Kita A, Younger SH, Zimmmerman S, Jan LY, and Jan YN. (2008) Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nature Cell Biology 10: 1172-1180. PMID: 18758451 [link]
Ye B*, Zhang Y*, Song W, Younger SH, Jan LY, and Jan YN. (2007) Growing dendrites and axons differ in their reliance on the secretory pathway. Cell 130:717-729. PMID: 17719548 [link]
Ye B*, Zhang Y*, Jan LY, and Jan YN. (2006) The secretory pathway and neuron polarization. Journal of Neuroscience 26:10631-10632. PMID: 17050701 [link]
*, equal contribution